• School of Pharmacy
• University of Wisconsin
• 777 Highland Avenue
• Madison, WI 53705-2222

Gururaj Joshi, Ph.D.

Scientist

Assistant Scientist
6226/28 Rennebohm Hall
Phone:608-262-4789
FAX: 608-262-5345

Overview

Effect of transcription factor Nrf2 activation on the onset and progression of Alzheimer's disease (AD) in AD-mouse Models. Dr. Joshi works with Professor Jeffrey Johnson to examine the role of a defense system present in the cells that surround and aid the Cortical and hippocampal neurons. With mice that make more than the usual amount of Nrf2 in astrocytes, Dr. Joshi investigates to see if the defense system might be reinforced for AD by crossing Nrf2 over-expressing mice with transgenic APP/PS-1 mouse model for AD. Dr. Joshi seeks to define whether the Nrf2 system is a way to affect the disease process and therefore a promising avenue toward effective therapy.

Work-Related Interests/Research:

Effect of transcription factor Nrf2 activation on the onset and progression of Alzheimer's disease (AD) in AD-mouse Models.

Member of Faculty Lab:

• Jeffrey Johnson