UW-Madison School of Pharmacy

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Glen S Kwon, Ph.D.

Professor
Professor, Jens T. Carstensen Distinguished Chair

 

 

 


We actively pursue pharmaceutical research in nanomedicine that focuses on polymeric assemblies for drug delivery, non-viral gene delivery and optical imaging. Within this context, we are very interested in fundamental pharmaceutical concepts in drug solubilization, controlled release and drug targeting. These insights into polymeric assemblies allow us to explore therapeutic strategies that involve novel nanomedicines that are bio-responsive, synergistic and theranostic, aiming for progress against lung, breast and ovarian cancers and also systemic fungal diseases.

Background:

Dr. Kwon was a Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellow at the Institute of Advanced Biomedical Engineering and Science at Tokyo Women's Medical University in Tokyo, Japan from 1991 to 1993 and an Assistant Professor in the Faculty of Pharmacy and Pharmaceutical Sciences at the University of Alberta in Edmonton, Canada from 1993 to 1997. He received the Jorge Heller Journal of Controlled Release/Controlled Release Society (CRS) Outstanding Paper Award in 1994 and the CRS Young Investigator Research Achievement Award in 2003. In 2012, he became a Fellow of the American Association of Pharmaceutical Scientists.

Dr. Kwon is co-founder of Co-D Therapeutics Inc., a start-up company dedicated to novel multi-drug anticancer nanomedicines. He is a member of the Experimental Therapeutics Program at the UW Carbone Cancer Center. He is a member of the Board of Scientific Advisors in CRS. He is an Associate Editor for the J. of Pharmacy and Pharm. Sci. He serves on editorial boards of J. Controlled Release, Pharm. Res., Exp. Biology & Med., Recent Patents and Drug Formulations and Molecular Pharmaceutics.

Professional Interests:

Nanomedicine; polymeric micelles; drug solubilization; controlled release; drug targeting; antifungal drug delivery; and optical imaging of cancer.

Education:

  • B.S. 1986 Chemistry - University of Utah
  • Ph.D. 1991 Pharmaceutics - University of Utah
  • Postdoc 1993 Bioengineering - Tokyo Women's Medical University
Highlighted Publications:
  • H. Cho and G. S. Kwon, "Thermosensitive poly(d,l-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(d,l-lactide-co-glycolide) hydrogels for multi-drug delivery," J. Drug Targeting, 22, 669-677 (2014).
  • T. C. Lai, H. Cho and G. S. Kwon, "Reversibly core cross-linked polymeric micelles with pH- and reduction-sensitivites: effects of cross-linking degree on particle stability, drug release kinetics, and anti-tumor efficacy," Polym. Chem., 5, 1650-1661 (2014).
  • H. Cho, C. S. Cho, G. L. Indig, A. Lavansanifar, M. R. Vakili, and G. S. Kwon, "Polymeric micelles for apoptosis-targeted optical imaging of cancer and intraoperative surgical guidance," PLoS One, 9, e89968 (2014).
  • T. Yoshida, T. C. Lai, G. S. Kwon, and K. Sako, "pH- and ion-sensitive polymers for drug delivery," Expert Opin. Drug Deliv., 10, 1497-1513 (2013).
  • H. Cho, T. C. Lai, and G. S. Kwon, "Poly(ethylene glycol)-block-poly(epsilon-caprolactone) micelles for combination drug delivery: evaluation of paclitaxel, cyclopamine, and gossypol in intraperitoneal xenograft models of ovarian cancer,"J. Controlled Release, 166, 1-9 (2013).
  • J. R. Hasenstein, H. C. Shin, K. Kasmerchak, D. Buehler, K. R. Kozak, G. S. Kwon, and K. R. Kozak, "Antitumor activity of triolimus: a novel multi-drug loaded micelle containing paclitaxel, rapamycin, and 17-aag," Mol. Cancer Ther., 11, 2233-2242 (2012).
  • H. C. Shin, H. Cho, T. C. Lai, K. R. Kozak, J. M. Kolesar, and G. S. Kwon, "Pharmacokinetic study of 3-in-1 poly(ethylene glycol)-block-poly(D,L-lactic acid) micelles carrying paclitaxel, 17-allylamino-17-demethoxygeldanamycin, and rapamycin," J. Controlled Release, 163, 93-99 (2012).
  • T. C. Lai, K. Kataoka, and G. S. Kwon, "Bioreducible polyether-based pdna ternary polyplexes: balancing particle stability and transfection ability," Colloids Surf. B Biointerfaces, 99, 27-37 (2012).
  • H. Cho, G. L. Indig, J. Weichert, H-C Shin, and G. S. Kwon, "In vivo cancer imaging by poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles containing a near-infrared probe," Nanomedicine: Nanotechnology, Biology, and Medicine, 8, 228-236 (2012).
  • T-H. H. Chen, Y. Bae, D. Y. Furgeson, and G. S. Kwon, "Biodegradable hybrid recombinant block copolymers for non-viral gene transfection," Int. J. Pharm., 427, 105-112 (2012).
  • H. Cho and G. S. Kwon, "Polymeric micelles for neoadjuvant cancer therapy and tumor-primed optical imaging," ACS Nano, 5, 8721-8729 (2011).
  • H. C. Shin, A. W. Alani, H. Cho, Y. Bae, J. M. Kolesar, and G. S. Kwon, "A 3-in-1 polymeric micelle nanocontainer for poorly water-soluble drugs," Mol. Pharm., 8, 1257-1265 (2011).
  • T. C. Lai, K. Kataoka, and G. S. Kwon, "Pluronic-based cationic block copolymer for forming pdna polyplexes with enhanced cellular uptake and improved transfection ability," Biomaterials, 32, 4594-4603 (2011).
  • T. A. Diezi, J. K. Takemoto, N. M. Davies, and G. S. Kwon, "Pharmacokinetics and nephrotoxicity of amphotericin b-incorporated poly(ethylene glycol)-block-poly(n-hexyl stearate l-aspartamide) micelles ," J. Pharm. Sci., 100, 2064-2070 (2011).
  • A. W. Alani, Y. Bae, D. A. Rao, and G. S. Kwon, "Polymeric micelles for the ph-dependent controlled, continuous low dose release of paclitaxel," Biomaterials, 31, 1765-1772 (2010).
  • T. A. Diezi, Y. Bae, and G. S. Kwon, "Enhanced stability of peg-block-poly(n-hexyl stearate l-aspartamide) micelles in the presence of serum proteins," Mol. Pharm., 7, 1355-1360 (2010).
  • H. C. Shin, A. W. Alani, D. A. Rao, N. C. Rockich, and G. S. Kwon, "Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs," J. Controlled Release, 140, 294-300 (2009).
  • M. P. Xiong, J. A. Yáñez, G. S. Kwon, N. M. Davies, and M. L. Forrest, "A cremophor-free formulation for tanespimycin (17-aag) using peo-b-pdlla micelles: characterization and pharmacokinetics in rats," J. Pharm. Sci., 98, 1577-1586 (2009).
  • R. Vakil, K. Knilans, D. Andes, and G. S. Kwon, "Combination antifungal therapy involving amphotericin b, rapamycin and 5-fluorocytosine using peg-phospholipid micelles," Pharm. Res., 25, 2056-2064 (2008).
  • J. A. Yáñez, M. L. Forrest, Y. Ohgami, G. S. Kwon, and N. M. Davies, "Pharmacometrics and delivery of novel nanoformulated PEG-b-poly(epsilon-caprolactone) micelles of rapamycin," Cancer Chemother. Pharmacol., 61, 133-144 (2008).
  • Y. Bae, T. A. Diezi, A. Zhao, and G. S. Kwon, "Mixed polymeric micelles for combination cancer chemotherapy through the concurrent delivery of multiple chemotherapeutic agents," J. Controlled Release, 122, 324-330 (2007).