UW-Madison School of Pharmacy

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  • School of Pharmacy
  • University of Wisconsin
  • 777 Highland Avenue
  • Madison, WI 53705-2222

  • Office
  • Rm 5121; Labs 5218/5220 Rennebohm Hall

  • Phone: 608-890-0699
  • Fax: 608-262-5345




  • Xiong lab website

  • Xiong lab notebooks

photo

May P Xiong

Assistant Professor
Pharmaceutical Sciences

 

 

 


In general, research in the lab lies at the interface of material science, pharmaceutics, and engineering.

One direction for the lab is to create synthetic materials capable of delivering multiple types of drugs within a single payload. This could reduce the dose limiting toxicity associated with the individual drugs, while maximizing therapeutic effects. Polymeric micelles encapsulating both siRNA and drug have been developed in the lab, and have significantly relieved tumor burden in mouse xenograft tumor models. Targeting of the system with antibodies is a new direction for this project. Two other projects on this system, in collaboration with other labs, are also currently being pursued (1 graduate student position open). Chemistry, NMR, TLC, gel permeation chromatography, HPLC, cell culture, setting up rodent tumor models, are all frequently used techniques in this type of research.

Another direction in the lab revolves around 'lipogels' for chelation therapy. LipoGels are comprised of a gel-like core in liposomes. The design of lipoGels allows for ease of surface modifications, such as targeting ligands (e.g. heart) or incorporation of PEG to prolong blood circulation. Optimization and incorporating biodegradability into lipoGels is a new direction for this project (1 graduate student position open). Lipogels are also being investigated for chelation therapy (1 graduate student position open). Formulation of liposomes, nanogels, lipoGels, NMR, TLC, gel permeation chromatography, HPLC, setting up rat models of iron overload, etc, are all frequently used techniques in this project.

Education

  • (Postdoc) California Institute of Technology, Chemical Eng.
  • Ph.D. University of Wisconsin, Pharmaceutical Sci.
  • B.S. Marquette University, Biomedical Eng.

Awards and Honors

  • Howard Temin Pathway to Independence Award in Cancer Research
  • Kirschstein National Research Service Award
  • PhRMA Predoctoral Research Fellow in Pharmaceutics
  • NSF EAPSI Award
  • Gates Millenium Scholar

Fields of interest

  • Biomaterials
  • Drug delivery
  • Gene delivery
  • Chelation therapy

 

Highlighted Publications:
  • San Zeng, Arvinder Kapur, Manish Patankar, May P Xiong. "Formulation, characterization, and antitumor properties of trans- and cis-citral in the 4T1 breast cancer xenograft mouse model", (Pharm Res, in press), 2015
  • Yan Wang, Sheng Tu, Dana Steffen, May P Xiong. "Iron complexation to histone deacetylase inhibitors SAHA and LAQ824 can considerably improve pharmacokinetics in rats", J Pharm Pharm Sci, 17(4) 583-602, 2014
  • Yan Wang, San Zeng, Tien-Min Lin, Lisa Krugner-Higby, Doug Lyman, Dana Steffen, May P Xiong. "Evaluating the anticancer properties of liposomal copper in a nude xenograft mouse model of human prostate cancer: formulation, in vitro, in vivo, histology, and tissue distribution studies", Pharm Res, 31(11) 3106-3119, 2014
  • Yan Wang, Sheng Tu, Anatoly N. Pinchuck, May P. Xiong. "Active drug encapsulation and release kinetics from hydrogel-in-liposome nanoparticles", J Colloid Interface Sci. 406, 247-255, 2013
  • San Zeng, May P Xiong. "Trilayer micelles for combination delivery of rapamycin and siRNA targeting Y-box binding protein-1 (siYB-1)", Biomaterials, 54, 367-375, 2013
  • Hannah C Cohen, May P Xiong. "Non-cell autonomous RNA interference in mammalian cells: implications for in vivo-based RNAi delivery", J RNAi Gene Silencing, 7, 456-63, 2011