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Ardala Katzfuss, PhD

Teaching Faculty III

I am an Enzymologist and Molecular Biologist, with over 10 years of experience in characterization of molecular targets and development of mechanism-based selective inhibitors, from discovery to preclinical stage. I have ample experience in upstream and downstream processes, selection and characterization of essential proteins and metabolic pathways as selective drug targets. As a mechanistic enzymologist, my research has focused on the use of enzyme kinetics to explore the rate-limiting step(s) of the chemical and kinetic mechanisms of reaction of molecular targets for the development of highly selective and transition-state based inhibitors.

I've worked with several Neglected Tropical Diseases, with publications covering the characterization of enzyme drug targets from Trypanosoma cruzi, Trypanosoma brucei, Plasmodium falciparum, and Mycobacterium tuberculosis. I have a long track record of managing complex multi-centric research grants, contracts, and projects funded by the Bill and Melinda Gates Foundation and by the NIH/NIAID; and I have acted as consultant for CROs and CMOs interested in engaging in research sponsored by the US government. I have also mentored undergraduate and graduate students for over 10 years now.