UW-Madison School of Pharmacy

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Member of Faculty Lab:

  • Jeffrey Johnson
head shot image

Delinda Johnson, PhD

Scientist


 

 

 


Education:

  • PhD 2012 Molecular Toxicology (Neurotoxicology) - University of Wisconsin-Madison
  • BS 1987 University of Wisconsin-Madison
Highlighted Publications:

•      Johnson DA, Johnson JA. (2015). Nrf2-a therapeutic target for the treatment of neurodegenerative diseases. Free Radical Biology of Medicine. 2015 Aug 14. pii: S0891-5849(15)00471-2.

•     Béraud D, Hathaway HA, Trecki J, Chasovskikh S, Johnson DA, Johnson JA, Federoff HJ, Shimoji M, Mhyre TR, Maguire-Zeiss KA (2013). Microglial Activation and Antioxidant Responses Induced by the Parkinson's Disease Protein -Synuclein. J Neuroimmune Pharmacol. 2013 Mar;8(1):94-117

 •     Gan L, Vargas MR, Johnson DA, Johnson JA (2012). Astrocyte-specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-synuclein Mutant (A53T) Mouse Model. J Neurosci. 2012 Dec 5;32(49):17775-87.

•     Williamson TP, Amirahmadi S, Joshi G, Kaludov NK, Martinov MN, Johnson DA, Johnson JA. (2012). Discovery of potent, novel Nrf2 inducers via quantum modeling, virtual screening and in vitro experimental validation. Chemical Biology and Drug Design, 80(6):810-20.

•     Lapash Daniels CM, Austin EV, Rockney DE, Jacka EM, Hagemann TL, Johnson DA, Johnson JA, Messing A (2012). Beneficial effects of nrf2 overexpression in a mouse model of alexander disease. J. Neurosci. 32(31):10507-15.

•     Williamson TP, Johnson DA, Johnson JA. (2012). Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity. Neurotoxicology, 33(3):272-9.

•     Vargas MR., Johnson DA, Johnson JA. (2011). Decreased glutathione accelerates neurological deficit and mitochondrial pathology in familial ALS-linked hSOD1G93A mice model. Neurobiol Dis. 43(3):543-51.

 •     Gan L, Johnson DA, Johnson JA. (2010). Keap1-Nrf2 Activation in the Presence and Absence of DJ-1. Eur. J. Neurosci. 31(6):967-77.

•     Johnson DA, Amirahmadi S, Ward C, Fabry Z, Johnson JA (2010). The Absence of the Pro-Antioxidant Transcription Factor Nrf2 Exacerbates Experimental Autoimmune Encephalomyelitis. Toxicol. Sci. 114(2):237-46.   Highlighted Paper.

•     Son TG, Camandola S, Arumugam TV, Cutler RG, Telljohann RS, Mughal MR, Moore TA, Yu QS, Johnson DA, Johnson JA, Greig NH, Mattson MP. (2009). Plumbagin, a Novel Nrf2/ARE Activator, Protects Against Cerebral Ischemia. J Neurochem. 112(5):1316-26.

•     Chen PC, Vargas MR, Pani AK, Smeyne RJ, Johnson DA, Kan YW, and J.A. Johnson (2009). Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte. Proc Natl Acad Sci U S A. 106(8):2933-8.

•     Yates, MS, Tauchi, M, Katsuoka, F, Flanders, KC, Liby, KT, Honda T, Gribble, GW, Johnson, DA,   Johnson, JA, Burton, NC, Guilarte, TR, Yamamoto, M, Sporn, MB, and TW Kensler (2007).  Pharmacodynamic     Characterization of Chemopreventive Triterpenoids as Exceptionally Potent   Inducers of Nrf2-Regulated Genes. Mol Cancer Ther. 2007 Jan;6(1):154-  62.

•     Calkins, MJ, Jakel, RJ, Johnson, DA, Chan K, Kan YW and JA Johnson (2005). Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. Proc. Natl. Acad. Sci. USA. 102(1):244-9.

•     Li, J, Spletter, ML, Johnson, DA, Wright, LS, Svendsen, CN and JA Johnson (2004). Rotenone induced caspase 9/3 independent and dependent cell death in undifferentiated and differentiated human neural stem cells. J. Neurochem. 92(3):462-76.

•     Kraft, AD, Johnson, DA and JA Johnson (2004). Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult. J Neurosci. 24(5):1101-12.

•     Shih AY, Johnson DA, Wong G, Kraft AD, Jiang L, Erb H, Johnson JA, Murphy TH. Coordinate regulation of glutathione biosynthesis and release by nrf2-expressing glia potently protects neurons from oxidative stress. J Neurosci.2003;23:3394-3406.

•     Johnson, DA, Xu, W, Andrews, GK and JA Johnson (2002). Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice. J. Neurochem. 81(6):1233-1241.