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Mary S Hayney, PharmD, MPH, FCCP, BCPS

Professor (CHS)

Patients on immunosuppression for the management of their underlying diseases are at high risk of infection, including vaccine-preventable diseases.  Immunosuppression may affect vaccine responses.  The Hayney Laboratory conducts research studies of vaccine responses in immunosuppressed patient groups.

Mary joined the University of Wisconsin's School of Pharmacy in 1997. Her research interests are in host response to vaccination and protective effects, especially as they relate to immunosuppressed individuals. Her clinical practice is with the lung transplant group at the University of Wisconsin Hospital and Clinics. Her postdoctoral training was at the Mayo Clinic and Foundation in Clinical Pharmacology and Vaccine Research. Her laboratory studies responses to vaccines, particularly in immunosuppressed populations.

Professional Interests: Mechanisms of vaccine response


  • BS - University of Minnesota
  • PharmD - University of Minnesota College of Pharmacy
  • Residency - Pharmacy Practice at the Mayo Clinic and Foundation
  • Fellowship - Mayo Vaccine Research Group, Clinical Pharmacology Unit
  • MPH - University of Wisconsin School of Medicine and Public Health

Fellow of the University of Wisconsin Teaching Academy

Lung transplant clinic at the University of Wisconsin Hospital and Clinics

Highlighted Publications:
  • Caldera F, Farraye FA, Necela BM, Cogen D, Saha S, Wald A, Daoud ND, Chun K, Grimes I, Lutz M, Van Helden SR, Swift MD, Virk A Bharucha AE, Patel TC, Gores GJ, Dhumsri S, Hayney MS, Knutson KL. Higher cell-mediated immunie responses in patients with inflammatory bowel disease on anti-TNF therapy after COVID-19 Vaccination. Inflamm Bowel Dis 2022 Sept 14 ahead of print.  PMID: 36103272
  • Schell TL, Knutson KL, Saha S, Wald A, Phan HS, Almasry M, Chun K, Grimes I, Lutz M, Hayney MS, Farraye FA, Caldera F. Humoral immunogenicity of 3 COVID-19 messenger RNA vaccine doses in patients with inflammatory bowel disease.  Inflamm Bowel Dis 2022   PMID: 35396992
  • Manley HJ, Lacson EK, Aweh G, Li NC, Weiner DE, Miskulin DC, Hsu CM, Kapoian T, Hayney MS, Meyer KB, Johnson DS. Seroresponse to inactivated and recombinant influenza vaccines among maintenance hemodialysis patients. Am J Kidney Dis 2022 Ahead of print PMID: 35288216
  • Smelter D, Hayney M, Sakoula G, Rose W. Is the success of cefazolin plus ertapenem in methicillin-susceptible bacteremia based on release of interleukin 1-beta? Antimicrob Agents Chemother online ahead of print  PMID: 34978891
    Editor’s choice
  • Caldera F, Knutson K, Saha, S, Wald A. Phan H, Chun K, Grimes I, Lutz M, Hayney MS, Farraye F. Humoral Immunogenicity of mRNA COVID-19 vaccines among patients with inflammatory bowel disease and healthy controls. Am J Gastroenterol Publish Ahead of Print , doi: 10.14309/ajg.0000000000001570. PMID: 34797219
  • Caldera F, Wald A, Saha S, Smith R, McCrone S, Farraye FA, Hayney MS. Equivalent cellular and humoral immunity to varicella-zoster virus in patients with inflammatory bowel disease and health older adults for whom immunization is recommended. Clin Transl Gastroenterol 2022;13(1):e00446. https://10.14309/ctg. 0000000000000446.  PMID: 35060934
  • Barnes J, LeClair-Netzel M, Kalscheur N, Wagner M, Gracon E, Steingraber-Pharr M, Potter B, Caldera F, Hayney MS. Influenza vaccination medical waivers among health care workers at an academic health system.  Infect Control Hosp Epidemiol 2020; 41(8): 971-3. PMID 32493528
  • Ritscher AM, LeClair-Netzel M, Friedlander NJ, Howard Stewart DN, Wagner M, Kalscheur N, Caldera F, Hayney MS. Cross-sectional study of hepatitis B antibody status in health care workers immunized as children at an academic medical center in Wisconsin.  Vaccine 2020; 38(7):1597-1600. PMID 31955961
  • Engstrom KK, Sill DN, Schauer S, Malinowski M, Martin E, Hayney MS. Timeliness of Wisconsin immunization registry (WIR) data entry by Wisconsin pharmacies.  JAPhA 2020; 618-23. PMID 31953117
  • Caldera F, Hillman L, Saha S, Wald A, Grimes I, Zhang Y, Sharpe AR, Reichelderfer M, Hayney MS. Immunogenicity of high dose influenza vaccine for patients with inflammatory bowel disease on antiTNF monotherapy: A randomized clinical trial. Inflamm Bowel Dis 2020; 26(4): 593-602.     PMID 31504526
  • Sharpe AR, LeClair-Netzel M, Wagner, M, Kalscheur N, Berlin KJ, Caldera F, Hayney MS. Healthcare worker influenza vaccine waivers at an academic health system. Infect Control Hosp Epidemiol 2019;40(7): 826-8. PMID 31072415
  • Caldera F. Hayney MS, Cross RK. Using number needed to harm to put the risk of herpes zoster from tofacitinib in perspective.  Inflamm Bowel Dis. 2019; 25(6): 955-7.   PMID 30605536
  • Caldera F, Misch EA, Saha S, Wald A, Zhang Y, Hubers J, Megna B, Ley D, Reichelderfer M, Hayney MS. Immunosuppression does not affect antibody concentrations to measles, mumps, and rubella in patients with inflammatory bowel disease.  Dig Dis Sci 2019;64(1):189-95. PMID: 30317494
  • Ritscher AM, Ranum N, Malak JD, Ahrabi-Fard S, Baird J, Berti AD, Curtis W, Holden M, Jones CD, Kind J, Kinsey W, Koepke R, Schauer L, Stein E, Van Orman S, Ward BG, Hayney MS. Meningococcal serogroup B outbreak response University of Wisconsin-Madison. J Am Coll Health 2019; 67(3): 191-6. PMID: 29952729
  • Barrett B, Hayney MS, Muller D, Rakel D, Brown R, Zgierska AE, Checovich MM, Barlow S, Hayer S, Barnet JH, Torres ER, Coe CL. Meditation or exercise for preventing acute respiratory infection (MEPARI-2): A randomized controlled trail.  PLOS-One 2018 13(6): e0197778.
  • Caldera F, Saha S, Wald A, Garmoe CA, McCrone S, Megna B, Ley D, Reichelderfer M, Hayney MS. Lower sustained diphtheria and pertussis antibody concentrations in inflammatory bowel disease patients.  Digest Dis Sci 2018; 63(6):1532-1540. PMID: 29594970
  • Rose WE, Shukla SK, Berti AD, Hayney MS, Henriquez KM, Ranzoni A, Cooper MA, Proctor RA, Nizet V, Sakoulas G. Increased intravascular Staphylococcus aureus inoculum is the link between elevated serum IL-10 concentrations and mortality in patients with bacteremia. Clin Infect Dis 2017;64(10):1406-12. PMID: 28205673
  • Miller RM, Rohde KA, Tingle MTA, Hayney MS. Antibody responses to influenza vaccine in pre-and post-lung transplant patients. Clinical Transpl 2016;30(5): 606-12.  PMID: 26928266
  • Rohde KA, Cunningham KC, Henriquez KM, Nielsen AR, Worzella SL, Hayney MS. A cross-sectional study of tetanus and diphtheria antibody concentrations post vaccination among lung transplant patients compared with healthy individuals. Transpl Infect Dis 2014; 16:871-7. PMID: 25180932
  • Hayney MS, Coe CL, Muller D, Obasi CN, Ewers T, Barrett B. Age and psychological influences on immune responses to trivalent inactivated influenza vaccine in the meditation or exercise for preventing acute respiratory infection (MEPARI) trial. Hum Vaccines Immunother 2014;10:83 - 91; PMID: 24096366
  • Barrett B, Hayney MS, Muller D, Rakel D, Ward A, Obasi CN, Brown R, Zhang Z, Zgierska A, Gern J, West R, Ewers T, Barlow S, Gassman M, Coe CL. Meditation and exercise for preventing acute respiratory infection: A randomized controlled trial. Ann Fam Med 2012;10:337-346 PMID:22778122
  • Moran JJM, Rose WE, Darga AJ, Rohde KA, Hayney MS.  Persistence of influenza vaccine-induced antibodies in lung transplant patients between seasons.  Tranpl Inf Dis 2011; 13:466-70. PMID: 21615847
  • Dopp JM, Wiegert NA, Moran JJ, Francois ML, Radford KL, Thomas H, Love RB, Hayney MS.  Effect of annual influenza immunization on antibody response in lung transplant patients. Prog Transplant 2009 Ju 19(2):153-9. PMID: 19588665
  • Hayney MS, Moran JJM, Weigert NA, Burlingham WJ. Lung transplant patients’ T cell responses to influenza vaccine viruses between seasons. Vaccine 2008;62:2596-2600. PMID: 18420314
  • Burlingham WJ, Love RB, Jankowska-Gan E, Haynes LD, Xu Q, Bobadilla JL, Meyer KC, Hayney MS, Braun, RK, Greenspan DS, Gopalakrishnan B, Yoshida S, Brand DD, Smith Jr. GN, Cummings OW, Cai J,  Wilkes DS. Col V specific, IL17- and monokine-dependent cellular immunity predisposes to obliterative bronchiolitis after lung transplantation. J Clin Invest 2007;117(11):3498-3506. PMID: 17965778
  • Hayney MS, Weigert NA, Pelsue FL, Fohl RM, Jankowska-Gan E, Love RB, Burlingham WJ. T cell responses to hepatitis B surface antigen in lung transplant patients. Pharmacotherapy 2007;27(9):1248-52. PMID: 17723078