head shot image

Sara Serag, B.Pharm, MS, PhD

Sara is trained as a pharmacist. She got her pharmacy degree from Egypt. Sara then joined the academic faculty of the clinical pharmacy department in the school of pharmacy, Ain Shams University. She taught for three years several courses including pharmacotherapy, pharmacokinetics, pharmacy practice, biostatistics and pathophysiology. Sara did a fellowship in Cardiovascular Clinical Research which involved pursuing several clinical trials evaluating the safety and efficacy of different drugs in patients suffering from heart failure and acute coronary syndrome.

Sara then started her graduate studies through the American University in Cairo. She did her masters in Tej K. Pandita's lab at UT-Southwestern, Dallas, TX. Her research involved identifying new regulators of telomeres maintenance, in addition to studying different regulators of DNA damage and repair.  

She then joined Bruce Spiegelman's lab at Harvard Medical School, where she did her PhD in brown fat metabolism and obesity. She graduated in April 2017 and joined the pharmaceutical sciences department in September 2017.

Sara is an instructor in Pharmacology I (PHMSCI 521) and Pharmacology II (PHMSCI 522) for DPH2.

She is also the course coordinator and instructor of Pharm 640 "Appropriate Use of Drugs of Abuse".

Highlighted Publications:

Chen Y, Zeng X, Huang X, Serag S, Woolf CJ, Spiegelman BM. Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity. Cell. 2017 Nov 2;171(4):836-848.e13.

Zeng X, Jedrychowski MP, Chen Y, Serag S, Lavery GG, Gygi SP, Spiegelman BM. Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation. Genes Dev. 2016 Aug 15;30(16):1822-36.

Concei o MS, Chacon-Mikahil MP, Telles GD, Libardi CA, J nior EM, Vechin FC, DE Andrade AL, G spari AF, Brum PC, Cavaglieri CR, Serag S, Spiegelman BM, Hawley JA, Camera DM. Attenuated PGC-1α Isoforms following Endurance Exercise with Blood Flow Restriction.Med Sci Sports Exerc. 2016 Se 48(9):1699-707.

Svensson KJ, Long JZ, Jedrychowski MP, Cohen P, Lo JC, Serag S, Kir S, Shinoda K, Tartaglia JA, Rao RR, Chédotal A, Kajimura S, Gygi SP, Spiegelman BM. A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell Metab. 2016 Mar 8;23(3):454-66

Singh M, Hunt CR, Pandita RK, Kumar R, Yang CR, Horikoshi N, Bachoo R, Serag S, Story MD, Shay JW, Powell SN, Gupta A, Jeffery J, Pandita S, Chen BP, Deckbar D, L brich M, Yang Q, Khanna KK, Worman HJ, Pandita TK. Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest. Mol Cell Biol. 2013 Mar;33(6):1210-22.