Sin Yin's research utilizes quantitative pharmacokinetics and pharmacodynamics (PK/PD) modeling approach to improve pharmacotherapy. His research has emphasized on understanding and quantifying the impact of physiological changes and pathological factors on drug disposition in pediatric population. He has utilized mechanistically- and physiologically-based PK, and population PK/PD modeling and simulation approaches to describe drug disposition and to evaluate and individualize dosing strategies in children. Currently, his research is focused on optimizing pain and sedation management in critically ill children, by studying biomarkers and developing a PK/PD model that can help identify tolerance to opioid and sedative therapy, reduce exposure of children to opioids, and avoid iatrogenic withdrawal syndrome.

Sin Yin received his PharmD degree and a MS in Clinical and Translational Science from the University of Oklahoma Health Sciences Center (OUHSC). He also completed a pharmacy residency and a pediatric pharmacotherapy fellowship with OUHSC before joining the School of Pharmacy at UW-Madison. 

PHARM 621 Pharmacokinetics
PHMSCI 756 Data Analyses in Drug Development
PHMSCI 768 Pharmacokinetics

• Malehorn EN, Blumenthal M, Miller JL, Stephens KS, Lewis TV, Lim SY, Johnson PN. Pharmacokinetic analysis of conventional tobramycin dosing for infants in the cardiac intensive care unit. Pediatr Res. 2026 Jun 11;. doi: 10.1038/s41390-026-05158-2. [Epub ahead of print] PMID: 42277183.
• Lim SY, Majeedi A, McAdams RM. Analgesia and sedation trends in a level IV NICU, 2014-2024: Opioid and dexmedetomidine use. J Perinatol. 2026 Apr;46(4):605-611. doi: 10.1038/s41372-026-02586-0. Epub 2026 Feb 23. PubMed PMID: 41731049; PMCID: PMC13121017.
• Thomas N, Harer MW, Lim SY. Physiologically Based Pharmacokinetic Modeling of Caffeine in Preterm Neonates: Influence of Renal Function and Impairment on Dosing. J Clin Pharmacol. 2026 Jan;66(1):e70135. doi: 10.1002/jcph.70135. Epub 2025 Nov 27. PubMed PMID: 41311102; PMCID: PMC12715538.
• Johnson A, Thomas N, Blumenthal M, Ikonomidou C, Lim SY. A Physiologically Based Modeling Approach to Evaluate Intravenous Levetiracetam Dosing in Term and Preterm Neonates. J Clin Pharmacol. 2025 Oct;65(10):1246-1261. doi: 10.1002/jcph.70037. Epub 2025 May 2. PMID: 40313172; PMCID: PMC12484410.
• Hughes S, Blumenthal M, Johnson A, Limjoco J, Lim SY. Pharmacokinetics and Pharmacodynamics of Levetiracetam in Neonatal Seizures: What We Still Need to Know. J Pediatr Pharmacol Ther. 2025 Apr;30(2):170-181. doi: 10.5863/1551-6776-30.2.170. Epub 2025 Apr 14. PubMed PMID: 40717753; PMCID: PMC12288557.
• Lim SY, Scarlett CO, Yapici S, Ferrazzano P, Cengiz P. Pharmacokinetics of 7,8-dihydroxyflavone in neonatal mice with hypoxia-ischemia related brain injury. Front Pharmacol. 2024;15:1508696. doi: 10.3389/fphar.2024.1508696. eCollection 2024. PMID: 39881861; PubMed Central PMCID: PMC11775835.
• Lim SY, Cengiz P. Opioid tolerance and opioid-induced hyperalgesia: Is TrkB modulation a potential pharmacological solution? Neuropharmacology. 2022 Dec 1;220:109260.
• Lim SY, May C, Johnson P, Miller L. Caffeine dosing in premature neonates: impact of birth weight on a pharmacokinetic simulation study. Petriatr Res. Jun 2022. doi: 10.1038/s41390-022-02172-y. PMID: 35717480. 
• Lim SY. Opioid effects on the central nervous system and the peripheral immune system: implications for opioid tolerance. Current Pharmacology Reports. 2021;7: 81–95. https://doi.org/10.1007/s40495-021-00258-5
• Lim SY, Miller JL, Henry E, Heltsley R, Woo S, Johnson PN. Analysis of Fentanyl Pharmacokinetics, and its Sedative Effects and Tolerance in Critically-Ill Children. Pharmacotherapy. Feb 2021. doi:10.1002/phar.2515.
• Lim SY*, Lewis TV*, Woo S, Bourne DWA, Burton ME, Turman MA, Rianthavorn P. Daptomycin pharmacokinetics in adolescents undergoing hemodialysis and peritoneal dialysis: a case series with pharmacokinetic modeling. *Equal contribution. J Pediatr Pharmacol Ther. 2021;26(2):123-132. doi: 10.5863/1551-6776-26.2.123 
• Lim SY, Sharan S, Woo S.  Model-based meta-analysis of cannabidiol dose-exposure relationship and bioavailability.  Pharmacotherapy.2020;40(4):291-300 doi: 10.1002/phar.2377
• Lim SY, Woo S, Miller JL, Skrepnek G, Henry E, Johnson PN.  Prediction and comparison of fentanyl infusion pharmacokinetics in obese and non-obese children.  Pediatr Crit Care Med. 2019; 20(12):e556-e564. doi: 10.1097/PCC.0000000000002125 
• Lim SY, Pettit R. Pharmacokinetic consideration in pediatric pharmacotherapy. Am J Health Syst Pharm. 2019; 76(19):1472-1480. doi: 10.1093/ajhp/zxz161

Complete publication list can be found at: https://www.ncbi.nlm.nih.gov/myncbi/sin%20yin.lim.1/bibliography/public/