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Ting Fu, PhD

Assistant Professor
Cancer Therapeutics and Precision Medicine

The Fu laboratory mainly studies how nuclear receptors sense environmental clues and regulate Gastrointestinal (GI) homeostasis in healthy and disease states. Specifically, we are interested in how dietary and microbial induced bile acids are sensed by Farnesoid X Receptor (FXR) and dynamically affect intestinal development, differentiation and inflammation, focusing on colorectal cancer (CRC) and Inflammatory bowel disease (IBD).

Graduate students and postdocs interested in joining our Lab are encouraged to email Dr. Fu.

Honors & Awards

  • 2020: AACR Scholar-in-Training Awards
  • 2019: Crohn’s Colitis Foundation IBD Visiting Scholar Fellowship
  • 2017: Kern Lipid Conference Early Career Investigator Awards
  • 2017-2019: Hewitt foundation for Medical Research Postdoc Fellowship Award
  • 2016: Salk Alumni Fellowship Award
  • 2015: Outstanding PhD Thesis Award
Highlighted Publications:
  1. Young-Chae Kim, Sunmi Seok, Xingchen Dong, Hao Sun, Byron Kemper, Ting Fu*, Jongsook Kim Kemper*. Impaired phosphorylation of SHP by FGF15/19 alters bile acids and gut bacteria, promoting nonalcoholic fatty liver disease. Journal Biological Chemistry, 2023. DOI:10.1016/j.jbc.2023.104946 PubMed PMID: 37348559 *,co-corresponding authorship.
  2. Xingchen Dong#, Chunmiao Cai#, Ting Fu . FXR suppress colorectal cancer by inhibiting the Wnt/β-catenin pathway via activation of TLE3. Genes and Diseases, 2022. DOI 10.1016/j.gendis.2022.09.006 
  3. Ting Fu#, Tao Huan#, Gibraan Rahman#, Hui Zhi, …, Manuela Raffatellu, Pieter C. Dorrestein, Michael Downes, Rob Knight*, Ronald M. Evans*. Paired microbiome and metabolome analyses associate bile acid changes with colorectal cancer progression. Cell Report. 2023 Aug;112997. DOI: 10.1016/j.celrep.2023.112997.  PubMed PMID: 37611587. (*, co-corresponding authorship. #, co-first authorship)
  4. Ting Fu, Yuwenbin Li, Tae Gyu Oh, Fritz Cayabyab, ...,Ye Zheng, Christopher Liddle, MichaelDownes*, Ronald M. Evans*, et al. FXR mediates ILC-intrinsic responses to intestinal inflammation. Dec 12, 2022, PNAS. DOI: doi/10.1073/pnas.2213041119.
  5. Ting Fu, Sally Coulter, Eiji Yoshihara, Tae Gyu Oh, Sungsoon Fang, Fritz Cayabyab, Qiyun Zhu,Michael Downes*, Ronald M. Evans*, et al. FXR regulates intestinal stem cell proliferation. VOLUME176, ISSUE 5, P1098-1112.E18, FEBRUARY 21, 2019, Cell.  DOI:
    -- Highlighted in a review article, Farnesoid X Receptor Suppresses Lgr5+ Cancer Stem CellProliferation, Cancer Discovery
    -- Highlighted in a review article, FXR regulates intestinal stem cells response to bile acids in a highfat diet, Biotarget
  6. Tae Gyu Oh, Susy Kim, Cyrielle Caussy, Ting Fu,…Michael R. Downes, Ronald M. Evans,* and Rohit Loomba,*et al. A Universal Gut Microbiome-Derived Signature for Predicting NAFLD-Cirrhosis Externally Validated with Geographically Independent Cohorts. Cell Metabolism.  DOI:
  7. Robert A. Quinn, Alexey V. Melnik, Alison Vrbanac, Ting Fu, …Ronald M. Evans, Victor Nizet, Rob Knight, and Pieter C. Dorrestein, et al. Global Chemical Impacts of the Microbiome Include Unique Bile Acid Conjugates that Stimulate FXR. Nature, 2020 Mar; 579(7797):123-129.  DOI:
  8. Ting Fu, Xuan Zhao, Ronald M. Evans. Liver Cancer Checks in When Bile Acid Clocks Out. Cancer Cell. 2016 Dec 12; 30(6):827-828. DOI: 10.1016/j.ccell.2016.11.012.
  9. Ting Fu, Jongsook Kim Kemper. MicroRNA-34a and impaired FGF19/21 signaling in obesity. VITAMINS & HORMONES, 2016 March 21; DOI: 10.1016/bs.vh.2016.02.002
  10. Ting Fu*, Youngchea Kim*, Dong-Hyun Kim, Sunmi Seok, Kelly Suino-Powell, H. Eric Xu, Byron Kemper and Jongsook Kim Kemper. FXR primes the liver for intestinal FGF15 signaling by transient induction of βklotho. Molecular Endocrinology, 2015 Oct 23; DOI:
  11. Sunmi Seok*, Ting Fu*, Sung-E Choi, Yang Li, Rong Zhu, Subodh Kumar, Xiaoxiao Sun, Gyesoon Yoon, Yup Kang, Wenxuan Zhong, Jian Ma, Byron Kemper, and Jongsook Kim Kemper. Transcriptional regulation of autophagy by an FXR/CREB1 axis. axis (*equal contribution to this work) Nature, 516, 108–111, 2014. (04 December 2014) DOI: 10.1038/nature13949
    -- Highlighted in a review article, Cell metabolism: Autophagy transcribed, C. Settembre & A. Ballabio, Nature
    -- Highlighted in a review article, Nutrient-sensing and autophagic genes in fed and fasted states Nature Reviews Endocrinology (2014)        
    -- Selected as a Faculty of 1000 Recommended Article
  12. Ting Fu, Sunmi Seok, Sung-E Choi, Zhang Huang, Kelly Suino-Powell, H. Eric Xu, Byron Kemper, and Jongsook Kim Kemper. MiR-34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte FGF21 signaling and SIRT1 function. Molecular and Cellular Biology, 2014, Nov 15; 34(22):4130-42. 
    -- Selected as the Spot light paper of the November Issue. 
  13. Ting Fu, SungE Choi, Dong-Hyun Kim, Sunmi Seok, Kelly Suino-Powell, H. Eric Xu, and Jongsook Kim Kemper. Aberrantly elevated miR-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor β-Klotho. PNAS, 2012 Oct 2; 109(40):16137-42.
    -- Highlighted in Science Daily, “In obesity, a microRNA causes metabolic problems”     
    -- Highlighted in News Medical, “A microRNA plays a key role in obesity”.      
    -- Highlighted in Genetic Engineering News “New target for obesity-related metabolic disorders”. 
  14. SungE Choi, Ting Fu, Sunmi Seok, Dong-Hyun Kim, Eunkyung Yu, Kwan-woo Lee, Yup Kang, Xiaoling Li, Byron Kemper, Jongsook Kim Kemper. Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. Aging Cell. 2013 Dec; 12(6):1062-72.