UW-Madison School of Pharmacy

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Weiping Tang, PhD

Professor
Director, Medicinal Chemistry Center

 

 

 


Organic Synthesis and Carbohydrate Chemistry:

We are interested in developing novel reactions for the synthesis of carbo- and heterocycles that are present in diverse bioactive polycyclic natural products and pharmaceutical agents. Currently, we are working on developing new methods for the synthesis and modification of biologically active alkaloids and carbohydrates.

Medicinal Chemistry and Drug Discovery:

We are interested in developing novel small molecules for treating human diseases and facilitating the study of complex cellular events. By collaborating with biologists in pharmaceutical companies and UW-Madison, we are currently developing novel compounds for the treatment of hyperlipidemia, diabetes, autoimmune diseases, cancer, and infectious diseases.

Chemical Biology:

We are interested in dissecting the complex biological pathways by novel small molecule probes. We are currently developing small molecules that can selectively perturb the secretory pathways and epigenetic modifications.

Background: Dr. Weiping Tang joined the faculty of UW-Madison in 2007. His lab focuses on synthetic organic chemistry, medicinal chemistry, and chemical biology. Please visit his lab website (link on the left) for updated information.

Education:

  • BS 1997 Chemistry - Peking University
  • MS 1999 Chemistry - New York University
  • PhD 2005 Organic Chemistry - Stanford University
  • Postdoc 2007 Medicinal Chemistry, Chemical Biology and Drug Discovery - Harvard University

Medicinal Chemistry II (PharmSci 532)

Natural Product Synthesis, Biosynthesis and Drug Discovery (PharmSci 786)

Highlighted Publications:
  • "Tumor Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction."  Jaskula-Sztul, R.; Eide, J.; Tesfazghi, S.; Dammalapati, A; Harrison, A.D.; Yu, X-M.; Scheinebeck, C.; Winston-McPherson, G.; Kupcho, K.R.; Robers, M.B.; Hundal, A.K.; Tang, W.;*Chen, H.* Mol. Cancer Therapy. 2015, 14, 499.
  • "Synthesis and Biological Evaluation of 2,3'-Diindolylmethanes as Agonists of Aryl Hydrocarbon Receptor."  Winston-McPherson, G.N.; Shu, D.; Tang, W.* Bioorg.Med.Chem.Lett. 2014, 24, 4023-4025.
  • "Stereoselective Preparation of Cyclobutanes with Four Different Substituents: Total Synthesis and Structural Revision of Pipercyclobutanamide A and Piperchabamide G." Liu, R.; Zhang, M.; Wyche, T. P.; Winston-McPherson, G. N.; Bugni, T. S.; Tang, W.* Angew. Chem. Int. Ed. 2012, 51, 7503-7506.
  • "Rhodium- and Platinum-catalyzed [4+3] Cycloaddition with Concomitant Indole Annulation: Synthesis of Cyclohepta[b]indoles" Shu, D.; Song, W.; Li, X.; Tang, W.* Angew. Chem. Int. Ed. 2013, 52, 3237-3240.
  • "Generation of Rhodium(I) Carbenes from Ynamides and Their Reactions with Alkynes and Alkenes." Liu, R.; Winston-McPherson, G. N.; Yang, Z.-Y.; Zhou, X.; Song, W.; Guzei, I. A.; Xu, X.;* Tang, W.* J. Am. Chem. Soc. 2013, 135, 8201–8204.
  • "Stereoselective Total Synthesis of Hainanolidol and Harringtonolide via Oxidopyrylium-Based [5+2] Cycloaddition" Zhang, M.; Liu, N.; Tang, W.* J. Am. Chem. Soc. 2013, 135, 12434-12438.
  • "Rhodium-Catalyzed Tandem Annulation and (5+1) Cycloaddition: 3-Hydroxy-1,4-Enyne as the 5-Carbon Component" Li, X.; Song, W.; Tang, W.* J. Am. Chem. Soc. 2013, 135, 16797-16800.