No longer accepting new graduate students.
Our laboratory is interested in the role of drug reduction pathways in the toxicity of arylamine compounds, including both therapeutic drugs and environmental carcinogens. Arylamines become toxic through the formation of hydroxylamine metabolites. We have characterized the enzymatic detoxification of hydroxylamines by a novel xenobiotic reduction pathway, comprised of cytochrome b5 and NADH cytochrome b5 reductase. We are working to identify pharmacogenetic variability in this pathway, and its relationship to drug hypersensitivity to the arylamine antimicrobial sulfamethoxazole. We are also examining the role of variability in the expression of cytochrome b5 and NADH cytochrome b5 reductase, and the development of DNA adducts in tissues exposed to the arylamine carcinogens.
Background: Lauren received her DVM from Cornell University (1986) and a PhD in Pharmacology from Cornell University (1997). She is board certified in Internal Medicine and Clinical Pharmacology. She joined the faculty of the School of Veterinary Medicine in 1997, and joined Pharmaceutical Sciences as an Affiliate Assistant Professor in 2001.
Professional Interests: Metabolic basis of idiosyncratic drug toxicity; pharmacogenetics.
